Phosphomevalonate

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August undefined, 2024

WebDec 10, 2013 · The classical mevalonate pathway is found in most eukaryotes, including humans; statin drugs are used to inhibit this pathway to treat those with high cholesterol and reduce the risk of heart disease. The second pathway does not use the compound mevalonate and is found in many, but not all, bacteria as well as the chloroplasts of plants. WebMar 5, 2024 · phosphomevalonate kinase. Gene ID: 10654, updated on 6-Sep-2024. Gene type: protein coding. Also known as: PMK; PMKA; PMKASE; POROK1; HUMPMKI. See all …

A [4Fe-4S] cluster resides at the active center of phosphomevalonate …

WebJan 27, 2014 · We have characterized the kinetic parameters of phosphomevalonate kinase (PMK, EC 2.7.4.2) from Saccharomyces cerevisiae, a previously unstudied enzyme. An E. coli codon-optimized version of the S. cerevisiae gene was cloned into pET-52b+, then the C-terminal 6X His-tagged protein was expressed in E. coli BL21(DE3) and purified on a Ni 2+ … WebAfter knockdown, regulators of cholesterol biosynthesis [sterol regulatory element–binding transcription factor 2 (SREBF2), HMGCR, HMGCS1, MSMO1, and phosphomevalonate … how to stop diapers for toddler

Phosphomevalonate kinase is a cytosolic protein in humans

Webmevalonate Applied Filters: Keyword: 'mevalonate' All Photos ( 1) (±)-Mevalonic acid 5-phosphate lithium salt hydrate Synonym (s): (±)-MVAP-Li, rac-5-Phosphomevalonate lithium salt Empirical Formula (Hill Notation): C6H13O7P · xLi+ · yH2O Molecular Weight: 228.14 (free acid basis) Match Criteria: Product Name, Keyword All Photos ( 1) WebPhosphomevalonate eluted at ∼0.35 m salt and contained <1% nucleotide, <5% pyruvate, and <1% P-enolpyruvate. The purified phosphomevalonate was loaded onto a 3-ml Fast-Q … WebAccession GO:0004631 Name phosphomevalonate kinase activity Ontology molecular_function Synonyms 5-phosphomevalonate kinase activity, ATP:(R)-5-phosphomevalonate phosphotransferase activity, ATP:5-phosphomevalonate phosphotransferase activity, mevalonate phosphate kinase activity, mevalonate-5 … reactive blazor

Phosphomevalonate Kinase - an overview ScienceDirect Topics

phosphomevalonate kinase activity - Gene Ontology

WebApr 1, 2004 · Phosphomevalonate kinase (PMK; EC 2.7.4.2.) catalyzes the fifth reaction of the pathway, which is the phosphorylation of phosphomevalonate to produce pyrophosphomevalonate. Several observations have led to the claim that PMK would be located predominantly in peroxisomes. WebFeb 21, 2024 · Phosphomevalonate kinase (PMVK) catalyzes the cation-dependent reaction of MVA-5P with ATP to form mevalonate 5-diphosphate (MVA-5PP) and ADP and … how to stop diarrhea 19764817WebAug 19, 2024 · Mevalonate kinase (MK) and phosphomevalonate kinase (PMK) are key enzymes in the MVA pathway. Little is known about the genes that encode MK and PMK in S. album or the mechanism that regulates ... how to stop diarrhea after chemo

"http://amigo.geneontology.org/amigo/term/GO:0004631 " - Phosphomevalonate

Phosphomevalonate

WebPhosphomevalonate kinase is an enzyme ( EC 2.7.4.2) in the mevalonate pathway [5] [6] [7] that in humans is encoded by the PMVK gene. Mevalonate pathway References [ edit] ^ a … WebPhosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13-1q22-23 and present a genomic map indicating that the gene spans more than 8.4 kb in the human …

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WebSep 17, 2024 · The decarboxylase [i.e., phosphomevalonate decarboxylase (PMD)] was recently identified from a halophilic archaeon, Haloferax volcanii ( 8 ), and a Chloroflexi bacterium, Roseiflexus castenholzii ( 9 ). The discovery substantiated the existence of the proposed modified pathway in these organisms. WebPhosphomevalonate kinase catalyzes the conversion of mevalonate-5- phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13-1q22-23 and present a genomic map indicating that the gene spans more than 8.4 kb in the human …

WebThe mevalonate pathway (MP) also known as the isoprenoid pathway or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway is an anabolic pathway providing … WebPhosphonates are one of the three sources of phosphate intake in biological cells. [citation needed] The other two are inorganic phosphate and organophosphates. The naturally …

WebNov 2, 2024 · We identified phosphomevalonate kinase (PMVK), a key mevalonate pathway enzyme, and sterol regulatory element-binding factor 2 (SREBF2), the master cholesterol … WebImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Phosphomevalonate kinase antibody (ab65806) Paraffin embedded rat skeletal muscle tissue stained for Phosphomevalonate kinase using ab65806 at 1 µg/ml in immunohistochemical analysis.

Webnoun. phos· pho· nate ˈfäs-fə-ˌnāt. : a salt or ester of a phosphonic acid. reactive blue 140 pubchemWebMar 13, 2024 · Reversible dehydration/hydration reaction catalyzed by phosphomevalonate dehydratase (PMDh), its bacterial homolog in the aconitase X (AcnX) family, and aconitase. PMDh assay in this study was performed viathe hydration reaction from trans-anhydromevalonate phosphate (tAHMP) to (R)-mevalonate 5-phosphate (MVA5P). how to stop diarWebThe galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP) superfamily encompases a wide-range of protein function. Three members of the family (mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonate decarboxylase) comprise the mevalonate pathway found in S. pneumoniae and other organisms. We have determined … reactive blueWeb216151 Ensembl ENSG00000099821 ENSMUSG00000020329 UniProt O00411 Q8BKF1 RefSeq (mRNA) NM_005035 NM_172551 RefSeq (protein) NP_005026 NP_766139 NP_001394721 NP_001394722 NP_001394723 NP_001394724 NP_001394725 NP_001394726 NP_001394727 NP_001394728 Location (UCSC) Chr 19: 0.62 – 0.63 Mb … reactive blood pressure vs hypertensionWebNov 1, 2024 · Phosphomevalonate kinase (PMK) is an important enzyme involved in the juvenile hormone (JH) biosynthesis pathway that catalyzes the phosphorylation of mevalonate 5-phosphate into mevalonate 5-diphosphate in the mevalonate pathway. Herein, we report the crystal structure of insect PMK from Bombyx mori. reactive blood pressureWebPhosphomevalonate kinase (PMK) catalyzes the next step in isoprenoid/sterol biosynthesis, converting mevalonate 5-phosphate and ATP to mevalonate 5-diphosphate and ADP. … reactive blue 224WebExpression of the ERG8 gene in S. cerevisiae from the galactose-inducible galactokinase (GAL1) promoter resulted in 1,000-fold-elevated levels of phosphomevalonate kinase … how to stop diarrhea 19764566