WebThe antibody recognises mono and oligomeric phospholamban when phosphorylated on serine-16 by PKA. Binding of the antibody to its target epitope is blocked in the presence of a phosphopeptide containing the PLB Phospho Ser-16 epitope. WebMay 31, 2024 · While phospholamban is a bona-fide therapeutic target, approaches to selectively inhibit this protein remain elusive. Here, we report the in vivo application of intracellular acting antibodies...
Blocking phospholamban with VHH intrabodies enhances ... - Nature
WebApr 13, 2024 · IntroductionObscurin (720–870 kDa) is a giant cytoskeletal and signaling protein that possesses both structural and regulatory functions in striated muscles. Immunoglobulin domains 58/59 (Ig58/59) of obscurin bind to a diverse set of proteins that are essential for the proper structure and function of the heart, including giant titin, novex … WebJan 31, 2011 · The regulatory interaction of phospholamban (PLN) with Ca 2+-ATPase controls the uptake of calcium into the sarcoplasmic reticulum, modulating heart muscle … great grandfather clipart
Phospholamban antisense oligonucleotides improve cardiac …
WebMay 12, 2024 · Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca 2+ -transport response to β-adrenergic stimulation, thus modulating cardiac output during the fight-or-flight response. Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca ) pump in cardiac muscle cells. See more This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase (PKA) in cardiac muscle. In the unphosphorylated state, phospholamban is an inhibitor of cardiac muscle … See more Gene knockout of phospholamban results in animals with hyperdynamic hearts, with little apparent negative consequence. Mutations in this gene are a cause of inherited human See more • PDBe-KB provides an overview of all the structure information available in the PDB for Human Cardiac phospholamban See more Phospholamban was discovered by Arnold Martin Katz and coworkers in 1974. See more PLN has been shown to interact with SLN and SERCA1. See more WebMay 12, 2024 · Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca 2+ -transport response to β-adrenergic stimulation, thus modulating cardiac … great grandfather creator