Dhhc palmitoyltransferase family
WebMar 21, 2024 · The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] WebA family of 23 mammalian DHHC-PATs has been identified and the majority of them are associated with many human diseases spanning from neuropsychiatric diseases to cancers. Novel unique and essential role of DHHC-mediated protein S-palmitoylation has been revealed apart from its membrane trafficking role. Biomedical importance of DHHCs has …
Dhhc palmitoyltransferase family
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WebDescription: Homo sapiens zinc finger DHHC-type palmitoyltransferase 14 (ZDHHC14), transcript variant 2, mRNA. (from RefSeq NM_153746) Gencode Transcript: ENST00000414563.6 ... SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. SIMILARITY: Contains 1 DHHC-type zinc finger. WebFeb 1, 2012 · Human palmitoylating enzymes (PATs) Palmitoylation is catalyzed by a family of enzymes that contain a DHHC (Asp-His-His-Cys) cysteine-rich domain which is directly involved in the palmitoyl transfer reaction (it is the apparent catalytic center of the enzyme) ( Mitchell et al., 2006 ). The DHHC cysteine-rich domain is a highly conserved …
WebJul 5, 2004 · Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Curated. Catalytic activity hexadecanoyl-CoA + L-cysteinyl- ... Belongs to the DHHC palmitoyltransferase family. Curated. Keywords. Domain. #Transmembrane; #Transmembrane helix; Phylogenomic databases. GeneTree. …
WebLike ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad … WebDHHC3 belongs to a family of DHHC palmitoyltransferase, which catalyzes the S-palmitoylation of target proteins by attaching a fatty acyl group to a cysteine. Recently, DHHC3 has been demonstrated to be a promising antitumor target in cancer therapeutics. However, the detailed structure and catalysis mechanism of DHHC3 remain elusive, …
WebBelongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. Contains 1 DHHC-type zinc finger. Domain. The DHHC domain is required for palmitoyltransferase activity. ... All lanes : Anti-DHHC-5 …
WebApr 1, 2015 · Identification of a Ras palmitoyltransferase in Saccharomyces ... S-acylation is mediated by a family of zinc finger DHHC domain-containing proteins encoded by 23 distinct ZDHHC genes in the ... ctl synWebJan 12, 2024 · Human DHHC20 palmitoyltransferase (yellow) shown localized in the Golgi body membrane (green stacks). ... Members of the DHHC family all use palmitoyl (acyl)–CoA and the same enzymatic chemistry to transfer an acyl group to substrate proteins. From this perspective, they are very similar to members of the family of protein … ctls user guideWebDESCRIPTION: RecName: Full=Probable palmitoyltransferase ZDHHC4; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 4; Short=DHHC-4; AltName: Full=Zinc finger protein 374; CATALYTIC ACTIVITY ... SIMILARITY: Belongs to the DHHC palmitoyltransferase family. earthquake 43cc 2 cycle mini cultivator mc43WebFeb 25, 2024 · Cysteine palmitoylation, a form of S-acylation, is a key posttranslational modification in cellular signaling. This type of reversible lipidation occurs in both plasma and organellar membranes, and is catalyzed by a family of integral membrane proteins known as DHHC acyltransferases. The first step … earthquake 43cc 2 cycle mini cultivatorWebDescription: Homo sapiens zinc finger DHHC-type palmitoyltransferase 21 (ZDHHC21), transcript variant 19, non-coding RNA. (from RefSeq NR_148718) ... SIMILARITY: Belongs to the DHHC palmitoyltransferase family. SIMILARITY: Contains 1 DHHC-type zinc finger. Comparative Toxicogenomics Database (CTD) The following chemicals interact with this … earthquake 3d modelsWebDHHC-type zinc finger family protein; S-acyltransferase involved in protein lipid modification; Belongs to the DHHC palmitoyltransferase family : 0.960: BPC7: Protein BASIC PENTACYSTEINE7; Transcriptional regulator that specifically binds to GA- rich elements (GAGA-repeats) present in regulatory sequences of genes involved in … earthquake® 33970 victorytm rear tine tillerWebNov 3, 2015 · The palmitoylation reaction is catalysed by TM-spanning enzymes called palmitoyl-S-acyl-transferases (PAT). One family of PATs is characterised by the presence of a conserved DH(H/Y)C motif, and certain apicomplexan organisms express more than 10 individual S-acyltransferases 8,14,17. They differ in localisation and timing of expression, … ctl sys/00f.58.4173 festool