Cyp17a1是什么
细胞色素 P450 17A1（英語：Cytochrome P450 17A1）也被称为甾体17α-单加氧酶（steroid 17α-monooxygenase），17α-羟基化酶（17α-hydroxylase），17,20-碳链裂解酶（17,20-lyase 或 17,20-desmolase）是一种羟基化酶，由位于人类10号染色体的 CYP17A1 基因编码 。这一基因在许多组织与细胞中都有表达，特别是肾上腺皮质的网状带（英语：zona reticularis）和 … WebMay 15, 2024 · Cytochrome P450 17A1 (CYP17A1) is a critical steroidogenic enzyme, essential for producing glucocorticoids and sex hormones. This review discusses the complex activity of CYP17A1, looking at its role in both the classical and backdoor steroidogenic pathways and the complex chemistry it carries out to perform both a …
Cyp17a1是什么
Did you know?
WebMar 5, 2009 · Cytochrome P450c17 catalyzes both 17-alpha-hydroxylation and 17,20-lyase conversion of 21-carbon steroids to 19-carbon precursors of sex steroids. In many species, the 17,20-lyase activity of P450c17 for one pathway dominates, reflecting the preferred steroidogenic pathway of that species. WebMar 21, 2024 · CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP17A1 include Adrenal Hyperplasia, Congenital, Due To 17-Alpha-Hydroxylase …
Web(A) Knockdown of Cyp17a1 specifically in the liver. (B and C) Fasting liver DHEA, blood-glucose, and b-hydroxybutyrate levels in mice fasted for 24 h with and without hepatic knockdown of Cyp17a1. WebJul 21, 2024 · 1. The gene encoding the CYP17A1 protein, which has both 17-hydroxylase and 17,20-lyase activities, contains eight exons and is located on 10q24.3 2.Defects in CYP17A1 reduce sex steroid and ...
WebCYP17A1 is strongly expressed in half about of human prostate carcinomas, implying an intracellular androgen synthesis by cancer cells. Abiraterone effectively blocked nuclear … WebMar 29, 2024 · Clinical resource with information about CYP17A1-AS1, Genome-wide association study of blood pressure and hypertension., Genome-wide association study …
WebCYP11A1 (D8F4F) Rabbit mAb. #14217. 使用 CYP11A1 (D8F4F) Rabbit mAb（绿色）对 NCI-H295R（左，阳性）和 SW-13（右，阴性）细胞进行共聚焦免疫荧光分析。. 肌动蛋 …
CYP17A1 is a member of the cytochrome P450 superfamily of enzymes localized in the endoplasmic reticulum. Proteins in this family are monooxygenases that catalyze synthesis of cholesterol, steroids and other lipids and are involved in drug metabolism. CYP17A1 has both 17α-hydroxylase activity (EC … See more Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the … See more Gene The CYP17A1 gene resides on chromosome 10 at the band 10q24.3 and contains 8 exons. The cDNA of this gene spans a length of … See more Mutations in this gene are associated with rare forms of congenital adrenal hyperplasia, specifically 17α-hydroxylase deficiency/17,20-lyase deficiency See more • Pregnenolone • 17α-Hydroxypregnenolone • Progesterone • 17α-Hydroxyprogesterone See more Expression of CYP17A1 has been found in all of the traditional steroidogenic tissues except the placenta, including the zona reticularis See more CYP17A1 inhibitors Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to the endogenous … See more • Biology portal • Steroidogenic enzyme • Cytochrome P450 oxidoreductase deficiency See more simplify 18/52WebCyp17a1: Gene Name: Cytochrome P450, family 17, subfamily a, polypeptide 1: Aliases: Cyp17, p450c17: RefSeq: NC_000085.6 NT_039687.8: Ensembl: … raymond ramirez attorneyWebBackground. CYP17A1, also known as cytochrome P450C17, is a steroidogenic enzyme belonging to the P450 cytochrome superfamily of monooxygenases (1, 2). In humans, CYP17A1 expression is abundantly expressed in the adrenal cortex, where it plays a central role in the androgen synthesis pathway (2). CYP17A1 is the primary target of … simplify 18/63Webcyp17a1是一种通过2步氧化反应，催化孕酮类化合物生成雄激素类化合物的酶。第一步反应是通过其羟化反应基团，羟基化c21的孕酮类化合物形成17α羟基孕酮类物质，第二步是通过其17碳链裂解酶基团，将c21的17α羟化孕酮类化合物转变为c19的雄激素类化合物，其后产物可在其他酶的作用下，还可继续 ... raymond rainbowWebThe CYP17A1 gene provides instructions for making a member of the cytochrome P450 enzyme family. Like other cytochrome P450 enzymes, CYP17A1 is involved in the … simplify 18/60WebCYP17A1 is the Branching Point of the Adrenal Steroidogenic Pathway. CYP17A1 is on Chromosome 15q23 and codes a 57 kDa enzyme that catalyzes two oxidase reactions … simplify 18/54WebSep 18, 2024 · cyp17a1基因突变可导致完全或者不完全17a-羟化酶/ 17, 20-裂解酶的缺乏, 临床表现为高血压、低钾血症、外生殖器发育异常。大多数突变位于基因的编码序列, 极少数的突变位于内含子区。本研究旨在探讨一种新型的基因突变, cyp17a1内含子突变对临床表型的 … simplify 18/63 answer